#SHAM 69 FACEBOOK TRIAL#

More than 1/4 of breast cancer patients developed new-onset insomnia during chemotherapy, and more likely to persist after the completion of cancer treatments than those without chemotherapy. Individuals under chemotherapy experienced higher incidence and more severe levels of insomnia than those who received other cancer treatments such as surgery and radiotherapy. Registered 30 October 2019.īreast cancer patients are at significantly greater risk of developing insomnia than those with other malignancies and the general population. It also could serve as a tapering approach to reduce and even replace the use of sleeping medications in breast cancer patients. The active acupuncture regimen could be considered as an effective option for the management of chemotherapy-associated insomnia. No participants discontinued treatments due to adverse events. All treatment-related adverse events were mild. Participants of the active acupuncture group had a pronouncedly higher cessation rate of sleeping medications than the sham control (56.5% vs.

The active acupuncture regimen was not superior to the sham control in reducing ISI score from baseline to 6 weeks (mean difference: − 0.4, 95% CI − 1.8–1.1 P = 0.609), but produced short-term treatment and long-term follow-up better outcomes in improving sleep onset latency, total sleep time, sleep efficiency, anxiety, depression, and quality of life. There were 87.7% (121/138) participants who completed the primary endpoint (week-6). Secondary outcomes included the Pittsburgh Sleep Quality Index, Actiwatch and sleep diary for sleep parameters, depression and anxiety, fatigue and pain, and quality of life. The primary outcome was measured using Insomnia Severity Index (ISI). The 138 breast cancer patients with chemotherapy-associated insomnia were randomly assigned to receive either 15 sessions of active acupuncture regimen by combining needling into body acupoints and acupressure on auricular acupoints or sham acupuncture control (69 each) for 18 weeks, followed by 24 weeks of follow-up. Assessments and interventions were conducted at the outpatient clinic of School of Chinese Medicine, the University of Hong Kong. Participants were referred by oncologists from two Hong Kong hospitals.

#SHAM 69 FACEBOOK TRIAL#

This assessor-participant blinded, randomized, sham-controlled trial was conducted from November 2019 to January 2022 (follow-up completed July 2022). This study was conducted to determine the efficacy and safety of acupuncture in improving chemotherapy-associated insomnia in breast cancer patients. Acupuncture may have beneficial effects in the management of chemotherapy-associated insomnia.

Insomnia is a highly prevalent symptom occurred during and post-chemotherapy.

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